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thorn
08.12.2006, 11:54
PCI через 3 – 28 дней после инфаркта миокарда у стабильных пациентов с окклюзией инфаркт-связанной артерии не снижала смертность, частоту развития повторных инфарктов и сердечной недостаточности в течение 4 лет наблюдения. Кроме того, отмечалась тенденция к увеличению частоты повторных инфарктов… Cсылка. ([Ссылки могут видеть только зарегистрированные и активированные пользователи])
Hochman JS, Lamas GA, Buller CE, Dzavik V, Reynolds HR, Abramsky SJ, Forman S, Ruzyllo W, Maggioni AP, White H, Sadowski Z, Carvalho AC, Rankin JM, Renkin JP, Steg PG, Mascette AM, Sopko G, Pfisterer ME, Leor J, Fridrich V, Mark DB, Knatterud GL. Coronary Intervention for Persistent Occlusion after Myocardial Infarction. N Engl J Med 2006;355:2395-407.

BACKGROUND: It is unclear whether stable, high-risk patients with persistent total occlusion of the infarct-related coronary artery identified after the currently accepted period for myocardial salvage has passed should undergo percutaneous coronary intervention (PCI) in addition to receiving optimal medical therapy to reduce the risk of subsequent events. METHODS: We conducted a randomized study involving 2166 stable patients who had total occlusion of the infarct-related artery 3 to 28 days after myocardial infarction and who met a high-risk criterion (an ejection fraction of <50% or proximal occlusion). Of these patients, 1082 were assigned to routine PCI and stenting with optimal medical therapy, and 1084 were assigned to optimal medical therapy alone. The primary end point was a composite of death, myocardial reinfarction, or New York Heart Association (NYHA) class IV heart failure. RESULTS: The 4-year cumulative primary event rate was 17.2% in the PCI group and 15.6% in the medical therapy group (hazard ratio for death, reinfarction, or heart failure in the PCI group as compared with the medical therapy group, 1.16; 95% confidence interval [CI], 0.92 to 1.45; P=0.20). Rates of myocardial reinfarction (fatal and nonfatal) were 7.0% and 5.3% in the two groups, respectively (hazard ratio, 1.36; 95% CI, 0.92 to 2.00; P=0.13). Rates of nonfatal reinfarction were 6.9% and 5.0%, respectively (hazard ratio, 1.44; 95% CI, 0.96 to 2.16; P=0.08); only six reinfarctions (0.6%) were related to assigned PCI procedures. Rates of NYHA class IV heart failure (4.4% vs. 4.5%) and death (9.1% vs. 9.4%) were similar. There was no interaction between treatment effect and any subgroup variable (age, sex, race or ethnic group, infarct-related artery, ejection fraction, diabetes, Killip class, and the time from myocardial infarction to randomization). CONCLUSIONS: PCI did not reduce the occurrence of death, reinfarction, or heart failure, and there was a trend toward excess reinfarction during 4 years of follow-up in stable patients with occlusion of the infarct-related artery 3 to 28 days after myocardial infarction.

exomen
09.12.2006, 18:35
Давно хотел поместить ссылку да все не найти времени////
здесь опубликована дисскусия вовлеченных в ОАТ специалистов о результатах, а также обсуждение другого исследования на эту тему TOSCA-2. ([Ссылки могут видеть только зарегистрированные и активированные пользователи]) ПОСТ № 10.

Dr.Vad
09.12.2006, 21:56
Как-то уже постил ссылку в другой теме по теме ОАТ с комментариями от канадских и британских экспертов по материалам медскейпа:

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