Просмотр полной версии : Быть высоким хорошо, но тромбо-опасно

Risk of VTE increased by 30–40% for each 10 cm increment in height.
Height was more strongly associated with deep vein thrombosis than with pulmonary embolism.
The pooled ORs from non-IV models and models using the full and restricted GRSs as IVs were 1.27 (95% confidence interval [CI] 1.11–1.46), 1.34 (95% CI 1.04–1.73) and 1.45 (95% CI 1.04–2.01) per 10-cm greater height, respectively.
Taller height is associated with an increased risk of VTE in adults of European ancestry. Possible explanations for this association, including taller people having a greater venous surface area, a higher number of venous valves, or greater hydrostatic pressure, need to be explored further.
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Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis
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еще две публикации на тему - риск тромбоза у высокорослых отмечался даже среди родных братьев и сестер - разница в 10 см повышала риск на треть:

Compared with the tallest women (>185 cm) and men (>190 cm), there was a graded decreased risk by lower height for both men and women. The risk was lowest in women and men with the shortest stature (<155 and <160 cm, respectively): hazard ratios=0.31 (95% confidence interval, 0.22-0.42) and 0.35 (95% confidence interval, 0.22-0.55), respectively. There was a graded association also in the cosibling design comparing siblings with varying degree of discordance for height (reference was the taller sibling): ≥10 cm difference between brothers hazard ratios=0.69 (95% confidence interval, 0.61-0.78) and sisters hazard ratios=0.65 (95% confidence interval, 0.52-0.80), respectively.
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Circ Cardiovasc Genet. 2017 Oct;10(5).
Body Height and Incident Risk of Venous Thromboembolism: A Cosibling Design.

Наличие тромбофилии не усиливало риск тромбоза у высокорослых, как это отмечалось при ожирении:

The VTE risk increased by increasing category of body height, and subjects with height ≥ 178 cm had a two-fold higher VTE risk (HR 2.03; 95% confidence interval [CI] 1.51-2.73) than those with height ≤ 165 cm. The VTE risk also increased across categories of risk alleles. However, the combination of a tall stature and risk alleles, either individual SNPs or risk score, did not result in an excess VTE risk. Subjects with four or more risk alleles and height ≥ 178 cm had a two-fold (HR 2.08; 95% CI 1.24-3.52) higher VTE risk than subjects ≤ 165 cm with no risk allele or one risk allele.
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J Thromb Haemost. 2018 Jan;16(1):83-89.
Joint effects of prothrombotic genotypes and body height on the risk of venous thromboembolism: the Tromsø study.